Newsgator is like an iPod...
I could go on for awhile about how Greg Reinacker's fantastic news reader, Newsgator, has changed my life, but I won't. I'll just say this: it's the most thought-through web-based news reader out there right now, and that includes Bloglines.
The difference between Newsgator and Bloglines is like that between an iPod and nearly any other MP3 player out there: Newsgator was designed for the middle of the bell curve by hiding non-critical functionality to simplify the user experience, while Bloglines was built for the early adopters, exposing functionality at the expense of ease of use.
If you are looking for a way to manage all the websites that you read, I suggest you check out Newsgator.